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Background: TORCH infection is responsible for the major of maternal and fetal morbidity and mortality in the pregnancy because of their ability to generate congenital defects. It transmits to foetus from the mother during gestation or delivery time and leads to serious complication to the foetus. It can lead to abortion, congenital anomalies and intrauterine fetal death. In fact, the most effective way to prevent the infection is a regular hand washing, particularly when caring for infected women and babies. The aim of this study is to assess the relationship between the rate of abortion and foetus death and TORCH infection as a major cause.
Methods: The data was collected from neonatal death certificates from the departments of gynaecology, obstetrics and neonates at Benghazi Medical Centre, which includes age groups, and causes of death, the data included all certificates from October 2014 to December 2018.
Results: The current study had showed that there was a significant elevation in the fetal and infant mortality rates from 2014 to 2018, and these numbers were increasing throughout the years without any medical reasons. High foetus death was observed at gestational period 33 -40 weeks, while the neonatal death was higher at age 1 to 30 days. Furthermore, this study reported that head and brain congenital anomalies were the most common between foetus and neonates and these findings were assumed that the death of the foetus and neonate could be caused by any of TORCH infections when compared to the previous studies.
Conclusion: Elevation rates of neonates and foetus were an obvious issue that must be of major concern, so that, the findings of this study emphasizing on the demand for doing TORCH test for all pregnant women at the first of pregnancy to early recognizing the infection. In addition, it is ensuring the demands of doing the TORCH test with the required HIV and hepatitis C tests before delivery to guide the staff take further attention. In addition, it emphasizes the need to focus on the effectiveness of hand hygiene, cleaning and disinfection in the department to reduce the rate of infection.
Deka D. Congenital intrauterine TORCH infections. New Delhi Jaypee Brothers. 2011;224:8.
Das S, Ramachandran VG, Arora R. Cytomegalovirus and rubella infection in children and pregnant mothers-A hospital based study. The Journal of Communicable Diseases. 2007;39(2):113-117.
Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. The American Journal of Pathology. 2007;170(4):1178-1191.
Tiwari S, Arora BS, Diwan R. TORCH IgMseroprevalence in women with abortions as adverse reproductive out-come in current pregnancy. Int J Res Med Sci. 2016;4(3):784-788.
Kaur R, Gupta N, Nair D, Kakkar M, Mathur MD. Screening for TORCH infections in pregnant women: A report from Delhi. Southeast Asian Journal of Tropical Medicine and Public Health. 1999; 30(2):284-286.
Mladina N, Mehikić G, Pasić A. Torch infections in mothers as a cause of neonatal morbidity. Medicinskiarhiv. 2000; 54(5-6):273-276.
Sebastian D, Zuhara KF, Sekaran K. Influence of TORCH infections in first trimester miscarriage in the Malabar region of Kerala. African Journal of Microbiology Research. 2008;2(3):56-59.
Sadik MS, Fatima H, Jamil K, Patil C. Study of TORCH profile in patients with bad obstetric history. Biology and Medicine. 2012;4(2):95.
The Center for Food Security and Public Health. Toxoplasmosis; 2017.
CDC. Parasites - Toxoplasmosis (Toxoplasma infection); 2018.
WHO. Rubella; 2019.
Hamdan HZ, Abdelbagi IE, Nasser NM, Adam I. Seroprevalence of cytomega-lovirus and rubella among pregnant women in western Sudan. Virology Journal. 2011;8(1):217.
Kesson AM. Management of neonatal herpes simplex virus infection. Paediatric Drugs. 2001;3(2):81-90.
CDC. Rubella transmission; 2017.
Wilson-Davies ESW, Aitken C. When should the ‘TORCH’ study be requested? Paediatrics and Child Health. 2013;23(5): 226-228.
Padmavathy M, Gowri M, Malini J, Umapathy BL, Navaneeth BV, Bhatia M, Harle S. Seroprevalence of TORCH infections and adverse reproductive outcome in current pregnancy with bad obstetric history. J Clin Biomed Sci. 2013; 3(2):62-71.
Pizzo JD. Focus on diagnosis: Congenital infection. Ped. In Review. 2011;32:537-542.
CDC. Babies Born with CMV (Congenital CMV Infection); 2018.
Song YH, Lee GM, Yoon JM, Cheon EJ, Lee SK, Chung SH, Lim JW. Trends in fetal and perinatal mortality in Korea (2009–2014): Comparison with Japan and the United States. Journal of Korean Medical Science. 2017;32(8):1319-1326.
WHO. Congenital Anomalies; 2016.
Zeb MA, Jamal SF, Mir A, Khan AA. Frequency of torch infections during pregnancy in Peshawar, Pakistan Muhammad Asif Zeb1, Shah Faisal Jamal1, Awal Mir2, Aamir Ali Khan3 and Aman Ullah1.
WHO. Investment case for eliminating mother-to-child transmission of syphilis; 2012.
Prasoona KR, Srinadh B, Sunitha T, Sujatha M, Deepika MLN, Lakshmi BV, Ramaiah A, Jyothy A. Seroprevalence and influence of torch infections in high risk pregnant women: A large study from South India. The journal of Obstetrics and Gynecology of India. 2015;65(5):301-309.
WHO. The WHO application of ICD-10 to deaths during the perinatal period: ICD-PM; 2016.
Newman L, Kamb M, Hawkes S, Gomez G, Say L, Seuc A, Broutet N. Global estimates of syphilis in pregnancy and associated adverse outcomes: Analysis of multinational antenatal surveillance data. PLoS Medicine. 2013;10(2):e1001396.
Miller E, Fairley CK, Cohen BJ, et al. Immediate and long term outcome of human parvovirus (B19) infection in pregnancy. Br J Obstet Gynaecol. 1998;105:174-178.
Xiong YQ, Tan J, Liu YM, He Q, Li L, Zou K, Sun X. The risk of maternal parvovirus B19 infection during pregnancy on fetal loss and fetalhydrops: A systematic review and meta-analysis. Journal of Clinical Virology; 2019.
Li X, Li M, Yang Z. Congenital TORCH infections of the brain-CT manifestation (with analysis of 7 cases). Chinese Journal of Radiology. 1997;31(3):160-163.
Malinger G, Lev D, Zahalka N, Aroia ZB, Watemberg N, Kidron D, Sira LB, Lerman-Sagie T. Fetal cytomegalovirus infection of the brain: The spectrum of sonographic findings. American Journal of Neuroradiology. 2003;24(1):28-32.
Sunitha T, Prasoona KR, Kumari TM, Srinadh B, Deepika MLN, Aruna R, Jyothy A. Risk factors for congenital anomalies in high risk pregnant women: A large study from South India. Egyptian Journal of Medical Human Genetics. 2017;18(1):79-85.